Measure content performance. Develop and improve products. List of Partners vendors. Raspberry ketones are aromatic bioactive phytochemicals found in red raspberries Rubusidaeus and other red fruits that are extracted and used in perfumes and cosmetics. They're also used as flavoring agents in some fruit-flavored foods. While raspberry ketones work well for those purposes, they're also often touted as a weight loss aid.
Despite raspberry ketones being marketed as a natural weight loss aid, there has been only one study that looked into raspberry ketones and weight loss in humans. A industry-funded clinical trial showed that a multi-ingredient weight loss product, which contained raspberry ketones among its ingredients, decreased body weight, body fat mass, and waist and hip girth in subjects with obesity a significant amount.
The study was sponsored by companies that make these supplements. Note that raspberry ketones were only one of many ingredients in the studied product—whether they specifically were responsible for the weight loss or if it was the combination of ingredients is unclear. Older research from aimed to determine if raspberry ketones help to prevent obesity and turn on fat energy storage.
The rats were fed a high-fat diet with varying amounts of raspberry ketone for six weeks. Researchers discovered that raspberry ketones prevented weight gain in the rodents' body generally, and more specifically in the liver and belly fat. That said, a study investigated the effect of raspberry ketones on adipose fat gain, liver fat storage, and adiponectin a protein hormone responsible for metabolic processes plasma levels in mice on a high-fat diet and found that supplementing raspberry ketones had a "limited benefit" for weight loss.
Another study explored whether raspberry ketones would have any effect on white adipose tissue—fat that results from excess calorie intake—acquiring characteristics of brown adipose tissue, which generates heat by burning calories. Researchers learned that raspberry ketones "significantly induced browning" of certain cells, reduced body weight gain, and limited food intake, among other benefits, in rats with obesity. They concluded that the study's findings provided some evidence to support using raspberry ketones clinically to treat obesity.
Currently, there is no reliable scientific evidence to support raspberry ketones as a weight-loss supplement for humans. Stimulant-like effects, including increased heartbeat and high blood pressure, are not uncommon in people taking raspberry ketones.
Raspberry ketones may possibly have damaging effects on the heart muscle and teratogenic consequences abnormal fetal developments due to drugs, chemicals, or infections. They might also negatively interact with drugs used to treat diabetes and blood clotting medications like warfarin. Raspberry ketone supplements are available in capsule, tablet, liquid, and powder form. The dosage varies from to milligrams per day, which is notably higher than what a person would consume in a regular serving of fruit or in the form of flavorings.
Some brands that sell raspberry ketone supplements claim to be all-natural or state that their product is made with natural ingredients.
These claims can be misleading, as most manufacturers use synthetic ketones. Even though raspberry ketones are naturally found in raspberries, the amount found in a single raspberry is minuscule and expensive to obtain.
When choosing a supplement, it's best to look for one that has been approved through a third-party verification company that has checked the quality of the product. As supplements do not require FDA approval to be sold, it is the manufacturer's responsibility to ensure that their product is of good quality and safe to consume. Be wary of supplements that claim to be free from side effects, have the ability to fix a problem or cure a disease, or deem themselves to be completely and totally safe.
Finally, adding raspberries to your diet is also an option. No studies have directly assessed the role of raspberries or raspberry ketones in humans who have dementia or have a higher risk of developing it. Some research has looked at how ellagic acid, a phytochemical in raspberries, affects the formation of amyloid plaques. The study showed that ellagic acid might slow the development of plaques. If this is the case, eating whole raspberries may be more beneficial than taking raspberry ketones as a supplement.
However, more research is necessary to confirm this potential benefit. As there have not been well-designed clinical trials involving humans, doctors and researchers do not know whether raspberry ketones are safe. Scientists are also unclear whether certain groups may be at greater risk of raspberry ketone side effects than others.
In one case , a woman using raspberry ketones experienced organ failure. She was also using other weight loss supplements, so doctors do not know whether raspberry ketones played a role. Isolated case reports suggest that ketones might cause side effects similar to those of supplements.
These can include:. People considering using raspberry ketones should consult a doctor first. Speaking to a doctor before taking raspberry ketones is particularly important for people who:. Women who are pregnant or breastfeeding should be especially skeptical of ketones. Children should not take weight loss supplements. There is no approved dosage for raspberry ketones. However, research generally focuses on ketones as a specific percentage of the diet rather than a fixed dosage.
People who want to try ketones at lower doses than supplements provide could try eating large quantities of raspberries. Fresh raspberries contain ketones in their natural state, not synthetic ketones.
They are also generally safe, though eating large amounts of any fruit can cause diarrhea in some people. There is no clinical data on potential drug interactions with raspberry ketones. Researchers have not yet conducted sufficient research to know how raspberry ketones might interact with other drugs.
Therefore, people taking other medications should not take ketones, as this could be unsafe. There is no evidence that raspberry ketones cause weight loss in humans and no reason to believe that they work better than traditional weight loss strategies.
Although the existing body of research on the other health benefits of ketones is hopeful, researchers must conduct more trials to confirm the effects of these compounds on the body. People who hope to get the benefits of raspberry ketones without the risk should consider eating more raspberries. Those who want to try ketones in supplement form should consult a doctor or dietitian first.
The diet can have a significant impact on the brain's function. A brain-healthy diet, rich in antioxidants and omega-3 fatty acids, can boost memory…. People who follow the ketogenic diet eat a low-carbohydrate, high-fat diet to induce a bodily process called ketosis.
Department of Defense Human Performance Resource Center deems the weight loss evidence on raspberry ketone as "insufficient. The U. However GRAS status is given under the assumption that a person will consume less than two milligrams of raspberry ketone a day. Most weight loss supplements pack far more raspberry ketone into their products.
Raspberry ketone is not well studied at concentrations used in supplements — which can range from 50 to milligram per serving. And there are some known side effects from their use. So, people taking drugs for diabetes should be monitored closely by their healthcare team.
Raspberry ketone may also cause changes in body fat and weight, changes in inflammation, heart palpitations and shakiness. Raspberry ketone may also interact with medicines, such as those that regulate heart rate and cholesterol, and hormones. In a study , published in the journal Regulatory Toxicology and Pharmacology, researchers in Denmark used a model to look at the potential effects of raspberry ketone on the human body.
Their findings suggested that raspberry ketone could have potentially toxic effects on the heart, as well as effects on the reproductive system. Editor's Note: This reference article was first published Sept. Live Science.
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